A new reassortant highly pathogenic genotype of the avian influenza (HPAI) A(H5N1), commonly known as bird flu, has rapidly spread across the US and Canada, underlining the need for pandemic preparedness. Clade 2.3.4.4b H5N1 virus, which emerged in late 2021, has affected more than 485 bird species and 48 mammal species worldwide. Now, a new.